#pineal agenesis
- Anepiphysia — An extremely rare congenital malformation or embryonic developmental structural anomaly characterized by the partial or total absence of the pineal gland (epiphysis cerebri). Functionally, this severe bio-structural condition profoundly disrupts the endocrine secretion of melatonin, directly impacting the circadian rhythm, sleep-wake cycles, and neuroendocrine mechanisms of sexual maturation.