Acanthosis
Definition
A histopathological alteration consisting of the thickening of the prickle cell layer (stratum spinosum) of the epidermis, caused by the proliferation of malpighian cells. In a clinical macroscopic sense, the term is frequently associated with 'Acanthosis nigricans', a skin condition characterized by hyperpigmented, velvety, and rough plaques, predominantly localized in intertriginous areas (neck, axillae, groin), serving as an important cutaneous marker for insulin resistance, obesity, or endocrine disorders.
Bilingual Equivalents
- Acanthosis
- Epidermal thickening
Grammatical & Source Details
| Inflection Type | Feminine noun with regular plural and genitive endings. |
| Formation | Medical neologism derived from French 'acanthose' and Greek 'akantha' (spine). |
| Spelling / Pronunciation | [a.kan.ˈto.zə] |
| Source | Textbook of Advanced Histopathology and Cutaneous Diseases |
Contextual Usage Examples
RO: Examenul microscopic al biopsiei cutanate a confirmat prezența unei acantoze pronunțate, asociată cu hiperkeratoză moderată.
EN: Microscopic examination of the skin biopsy confirmed the presence of pronounced acanthosis associated with moderate hyperkeratosis.
RO: La pacienții cu sindrom metabolic, o acantoză vizibilă la nivelul gâtului poate indica o rezistență severă la insulină.
EN: In patients with metabolic syndrome, visible acanthosis on the neck can indicate severe insulin resistance.
RO: Medicul a explicat că această acantoză nu este o simplă problemă estetică, ci reflectă un dezechilibru hormonal intern.
EN: The physician explained that this acanthosis is not a simple cosmetic issue, but reflects an internal hormonal imbalance.
Idioms & Phrases
Acantoză nigricans (Acanthosis nigricans) / Acanthosis nigricans
RO: Formă clinică specifică de hiperpigmentare și îngroșare catifelată a pielii în zonele flexorii, corelată frecvent cu obezitatea sau diabetul zaharat.
EN: A specific clinical form of hyperpigmentation and velvety thickening of the skin in flexural areas, frequently correlated with obesity or diabetes mellitus.
Acantoză histologică regulată / Regular histological acanthosis
RO: Alungirea simetrică și uniformă a crestelor interpapilare ale epidermului, un aspect microscopic diagnostic întâlnit clasic în psoriazis.
EN: Symmetric and uniform elongation of the interpapillary ridges of the epidermis, a diagnostic microscopic feature classically found in psoriasis.
Acantoză malignă / Malignant acanthosis
RO: O variantă rară și severă de modificare cutanată care se dezvoltă rapid la adulți ca un sindrom paraneoplazic asociat unui adenocarcinom intern.
EN: A rare and severe variant of skin alteration that develops rapidly in adults as a paraneoplastic syndrome associated with an internal adenocarcinoma.
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