Alagille-related
Definition
The feminine singular form of the neological adjective 'alagic'; relating to, originating from, or structurally associated with Alagille syndrome, a rare systemic genetic disorder characterized by the hypoplasia of interlobular bile ducts, cardiovascular malformations, skeletal anomalies (butterfly vertebrae), and distinct facial features. In clinical terminology, it describes a pathological manifestation, an organic impairment, or a specific cellular anomaly diagnosed within this hereditary syndromic complex governed by mutations in the JAG1 or NOTCH2 genes.
Bilingual Equivalents
- Alagille-related
- Syndromic Alagille
Grammatical & Source Details
| Inflection Type | Feminine singular variable adjective. Plural: alagice. Genitive-dative: alagicei. |
| Formation | Eponymous adjective derived from physician Daniel Alagille, standardly integrated utilizing the functional relational suffix '-ic'. |
| Spelling / Pronunciation | [a.la.ˈdʒi.kə] |
| Source | Stedman's Medical Dictionary and Genetic Disorders Index Standards |
Contextual Usage Examples
RO: Echipa de medici a analizat o afectare hepatică alagică la un sugar care prezenta icter colestatic sever.
EN: The medical team analyzed an Alagille-related hepatic impairment in an infant presenting with severe cholestatic jaundice.
RO: Mutația genetică alagică identificată la testarea ADN-ului a confirmat suspiciunea clinică a pediatrului.
EN: The Alagille genetic mutation identified during DNA testing confirmed the pediatrician's clinical suspicion.
RO: Biopsia a relevat o structură alagică atipică a canalelor biliare, caracterizată prin penuria accentuată a acestora.
EN: The biopsy revealed an atypical Alagille-like structure of the bile ducts, characterized by their marked paucity.
Idioms & Phrases
Afectare alagică / Alagille syndrome manifestation
RO: Prezența simultană a colestazei cronice și a malformațiilor cardiace specifice eredității acestui sindrom.
EN: The simultaneous presence of chronic cholestasis and cardiac malformations specific to the heredity of this syndrome.
Facies cu structură alagică / Alagille facies
RO: Dismorfism facial caracteristic incluzând fruntea proeminentă, ochi adânciți în orbite și bărbie ascuțită.
EN: Characteristic facial dysmorphism including a prominent forehead, deep-set eyes, and a pointed chin.
Arhitectură alagică / Alagille-type biliary architecture
RO: Configurație histologică hepatică patologică definită prin distrugerea sau absența congenitală a căilor biliare mici.
EN: A pathological hepatic histological configuration defined by the destruction or congenital absence of small bile ducts.
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