Aminophylline
Definition
A stable complex composed of theophylline and ethylenediamine in a one-to-one molar ratio, widely used as a bronchodilator medication in the treatment of obstructive airway diseases, such as bronchial asthma and chronic obstructive pulmonary disease (COPD). Due to its xanthine component, it inhibits phosphodiesterase, increasing intracellular cyclic AMP levels, which leads to the relaxation of bronchial smooth muscle and direct relief of dyspnea attacks.
Bilingual Equivalents
- Aminophylline
- Miofilin
Grammatical & Source Details
| Inflection Type | Feminine noun, regular singular case variations utilized in standard pharmacological nomenclature. |
| Formation | Scientific compound formed from the prefixoid 'amino-' and the drug base '-phylline', adapted according to international chemical rules. |
| Spelling / Pronunciation | [a.mi.no.fi.ˈli.nə] |
| Source | European Pharmacopoeia Standards and Medical Formulary |
Contextual Usage Examples
RO: Medicul de gardă a administrat aminofilină intravenos pentru a opri atacul sever de astm bronșic al pacientului.
EN: The attending physician administered aminophylline intravenously to halt the patient's severe bronchial asthma attack.
RO: Tratamentul prelungit cu aminofilină trebuie însoțit de monitorizarea periodică a concentrației plasmatice pentru a evita toxicitatea.
EN: Prolonged treatment with aminophylline requires periodic monitoring of plasma concentration to avoid toxicity.
RO: Datorită interacțiunilor medicamentoase, doza de aminofilină trebuie ajustată dacă pacientul urmează un tratament concomitent cu antibiotice din clasa fluoroquinolonelor.
EN: Due to drug interactions, the aminophylline dose must be adjusted if the patient undergoes concurrent treatment with antibiotics from the fluoroquinolone class.
Idioms & Phrases
Concentrație de aminofilină / Aminophylline concentration
RO: Nivelul de substanță activă determinat din plasmă pentru ajustarea terapeutică precisă a dozelor administrate.
EN: The active substance level determined from plasma for the precise therapeutic adjustment of administered doses.
Aminofilină retard / Sustained-release aminophylline
RO: Formă farmaceutică structurală cu eliberare prelungită, utilizată în profilaxia de lungă durată a dispneei nocturne.
EN: A structural pharmaceutical formulation with extended release, utilized in the long-term prophylaxis of nocturnal dispnea.
Supradozaj cu aminofilină / Aminophylline overdose
RO: Stare toxică severă determinată de acumularea teofilinei, manifestată prin aritmii cardiace și excitabilitate nervoasă.
EN: A severe toxic state caused by the accumulation of theophylline, manifested by cardiac arrhythmias and nervous excitability.
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