Azole
Definition
A heterocyclic organic chemical compound characterized by a five-membered aromatic ring containing at least one nitrogen atom and other heteroatoms (such as nitrogen, sulfur, or oxygen); structurally, the azole class includes foundational compounds like imidazole or triazole, extensively used in medicine as antifungal and antimicrobial agents due to their capacity to inhibit ergosterol synthesis in fungal cells.
Bilingual Equivalents
- Azole
- Heterocyclic azole
Grammatical & Source Details
| Inflection Type | Masculine noun, regular plural 'azoli'. |
| Formation | Chemical neologism adapted from the prefix 'azo-' (nitrogen) combined with the standard organic suffix '-ole' for unsaturated rings. |
| Spelling / Pronunciation | [a.ˈzol] |
| Source | IUPAC Gold Book / Compendium of Chemical Terminology |
Contextual Usage Examples
RO: Medicul a prescris un unguent pe bază de azol pentru a trata infecția cutanată persistentă a pacientului.
EN: The doctor prescribed an azole-based ointment to treat the patient's persistent skin infection.
RO: Sinteza de laborator a demonstrat că acest nou azol prezintă o toxicitate mult mai scăzută asupra celulelor hepatice.
EN: The laboratory synthesis demonstrated that this new azole exhibits a much lower toxicity on liver cells.
RO: Inelul de azol joacă un rol esențial în legarea moleculei de situl activ al enzimei țintă.
EN: The azole ring plays an essential role in binding the molecule to the active site of the target enzyme.
Idioms & Phrases
Inel de azol / Azole ring
RO: Nucleu structural aromatic de cinci atomi ce servește ca schelet de bază în chimia multor medicamente moderne.
EN: A five-membered aromatic structural core that serves as a base skeleton in the chemistry of many modern drugs.
Antifungic din clasa azolilor / Azole antifungal
RO: Clasă de medicamente antimicotice utilizate pe scară largă pentru distrugerea membranei celulare a fungilor.
EN: A class of antimycotic medications widely used for disrupting the cellular membrane of fungi.
Derivat de azol / Azole derivative
RO: Compus chimic complex obținut prin modificarea structurală a inelului de bază pentru îmbunătățirea proprietăților farmacocinetice.
EN: A complex chemical compound obtained by structurally modifying the core ring to improve pharmacokinetic properties.
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